Gil R, Di Mario C, Serruys P W, Kornacewicz-Jach Z, Kazmierczak J
Klinika Kardiologii Pomorskiej Akademii Medycznej, Szczecin.
Kardiol Pol. 1993 Nov;39(11):376-82.
The local coronary flow in 42 patients (mean age: 59 +/- 9 years) with ischemic heart disease was assessed by means of an 0.018" intracoronary Doppler guidewire. Study population was divided into two groups: group I--"normal vessels" (diameter stenosis < 30%) and group II--"stenosis vessels" (diameter stenosis > 60%). Measurements of: averaged peak velocity (APV), diastolic-systolic velocity ratio (DSVR) were performed in proximal segments of normal vessels and proximally to stenosis in group II. APV and DSVR were recorded at rest (bas) and during papaverine induced hyperemia. Coronary flow reserve (CFR) was calculated as ratio hyperemic and resting values of APV. Mean value of APV at rest was highest for left main stem, lowest for venous by-passes (SVBG) but did not differ among three coronary arteries (LAD, LCX, RCA). CFR value was significantly higher for group I then for group II (2.75-3.3 vs 1.8-2.0) but did not differ significantly among particular arteries in both groups. Mean value of DSVRbas in both examined groups was lowest for right coronary artery and for SVBG (ca. 1.0) and did not change significantly during hyperemia. This value was significantly higher (ca. 2.0) for left coronary arteries (LAD, LCX) then for RCA and SVBG and significantly decreased after administration of papaverine.
采用0.018英寸冠状动脉内多普勒导丝对42例（平均年龄：59±9岁）缺血性心脏病患者的局部冠状动脉血流进行评估。研究人群分为两组：I组——“正常血管”（直径狭窄<30%）和II组——“狭窄血管”（直径狭窄>60%）。在正常血管近端节段以及II组狭窄近端进行平均峰值速度（APV）、舒张期-收缩期速度比值（DSVR）的测量。在静息状态（bas）和罂粟碱诱导的充血期间记录APV和DSVR。冠状动脉血流储备（CFR）计算为充血期和静息期APV值的比值。静息时APV的平均值以左主干最高，静脉旁路（SVBG）最低，但在三支冠状动脉（LAD、LCX、RCA）之间无差异。I组的CFR值显著高于II组（2.75 - 3.3对1.8 - 2.0），但两组中各动脉之间无显著差异。两个研究组中，右冠状动脉和SVBG的静息DSVRbas平均值最低（约1.0），充血期间无显著变化。左冠状动脉（LAD、LCX）的该值显著高于RCA和SVBG（约2.0），给予罂粟碱后显著降低。
