Romańczyk T, Nowakowska-Duława E, Nowakowska M, Rogala-Zawada D, Kłuciński P
Katedra i Klinika Gastroenterologii, Slaskiej Akademii Medycznej w Katowicach.
Med Dosw Mikrobiol. 1993;45(2):209-12.
Bismuth salts belong do basic drugs used for elimination of Helicobacter pylori (HP), a microorganism which is postulated to participate in etiopathogenesis of duodenal ulcer. The study was aimed at evaluation of effectiveness of application of tripotassium bismuth citrate (Ventrisol-Polfa) in elimination of HP and its influence on treatment of the ulcer. In 30 patients with diagnosed endoscopically duodenal ulcer, Ventrisol in tablets was applied (2 x 2); it was also used in its fluid form (4 x 5 ml). The time of treatment amounted to 28 days. During endoscopy, samples from various parts of the stomach were taken for microbiological inspection and they were studied in direct smear and in culture. HP was isolated from 20 out of 30 patients (37%) before treatment. After application of Ventrisol, the bacteria were present in 11/30 (34%) treated patients (p < 0.05). There was no influence of the form of drug for elimination of HP. No dependence was also found between elimination of HP and healing of the ulcer.
铋盐属于用于根除幽门螺杆菌（HP）的碱性药物，幽门螺杆菌被认为参与十二指肠溃疡的发病机制。本研究旨在评估枸橼酸铋钾（Ventrisol-Polfa）根除HP的有效性及其对溃疡治疗的影响。对30例经内镜诊断为十二指肠溃疡的患者，给予片剂形式的Ventrisol（2片，每日2次）；也使用其液体制剂（4次，每次5 ml）。治疗时间为28天。在内镜检查期间，从胃的各个部位采集样本进行微生物学检查，并进行直接涂片和培养研究。治疗前，30例患者中有20例（37%）分离出HP。应用Ventrisol后，11/30（34%）接受治疗的患者中存在该细菌（p<0.05）。药物剂型对根除HP没有影响。HP的根除与溃疡愈合之间也未发现相关性。
