Roeb E, Matern S
Innere Medizin III, Medizinische Fakultät der RWTH Aachen.
Leber Magen Darm. 1993 Dec;23(6):239-42.
Diffuse and chronic liver damage leads to scar formation of the liver structure accompanied with a disproportionate increase of the extracellular matrix (ECM) constituents. Therapeutic intervention in fibrogenesis with its serious clinical consequences requires analysis of structure and cellular sources of ECM. Fibronectin (FN) is a high molecular weight glycoprotein and increases first among ECM proteins during liver fibrosis. The following report summarizes the crucial aspects of FN during fibrogenesis. Besides its controvertible role as initiator or regulator of fibrogenesis FN plays an important role as a scaffold for other matrix proteins.
弥漫性慢性肝损伤会导致肝结构形成瘢痕，并伴有细胞外基质（ECM）成分不成比例的增加。对具有严重临床后果的肝纤维化进行治疗干预，需要分析ECM的结构和细胞来源。纤连蛋白（FN）是一种高分子量糖蛋白，在肝纤维化过程中是ECM蛋白中最先增加的。以下报告总结了肝纤维化过程中FN的关键方面。除了其作为肝纤维化启动子或调节因子的争议性作用外，FN作为其他基质蛋白的支架也发挥着重要作用。
