Balchen T, Berg M, Diemer N H
Institute of Neuropathology, University of Copenhagen, Denmark.
Neurosci Lett. 1993 Dec 12;163(2):151-4. doi: 10.1016/0304-3940(93)90369-v.
The pyramidal neuron loss in dorsal rat hippocampus was determined 4 days after i.p. administration of 10 or 20 mg/kg kainic acid (KA). Histological examination revealed that subtotal-to-total loss of the pyramidal neurons in both the CA3 and CA1 regions of hippocampus was produced after 10 mg/kg KA. At the higher dose, severe damage was evident in the CA3 region while no or only sporadic damage was observed in the CA1 region. These findings suggest that the high KA dose damaged the CA3 pyramidal neurons before excitatory input through the Schaffer collaterals produced irreversible damage to the CA1 pyramidal neurons.
在腹腔注射10或20mg/kg红藻氨酸（KA）4天后，测定大鼠背侧海马的锥体神经元损失。组织学检查显示，10mg/kg KA给药后，海马CA3和CA1区的锥体神经元出现部分至全部损失。在较高剂量时，CA3区有明显的严重损伤，而CA1区未观察到或仅观察到散在损伤。这些发现表明，高剂量KA在通过Schaffer侧支的兴奋性输入对CA1锥体神经元产生不可逆损伤之前，就已损伤了CA3锥体神经元。
