Ueki A, Kawano M, Namba Y, Kawakami M, Ikeda K
Department of Neurology, Jichi Medical School, Omiya Medical Center, Japan.
Neurosci Lett. 1993 Dec 12;163(2):166-8. doi: 10.1016/0304-3940(93)90373-s.
Phenotypes of apolipoprotein E (apo E) were determined by the iso-electric focusing method in 42 Japanese patients with nonfamilial late-onset Alzheimer's disease (AD) and 96 age-matched controls without hyperlipidemia and/or diabetes. There was a striking difference in the distribution of apo E phenotypes between patients with AD and controls (P < 0.0001). Such a difference was mostly attributable to different frequencies of phenotypes E4/3 and E3/3. The apo E4/3 phenotype was detected in 24 (57.1%) of 42 patients with AD, more than six times oftener than in nine (9.4%) of 96 controls. In contrast, apo E3/3, which is the most common apo E phenotype in various ethnic groups, was detected in only 15 (35.7%) patients with AD. These results indicate a strong association between apo E4 isoprotein and Japanese late-onset nonfamilial AD, and that apo E4 is a possible risk factor for the development of this type of AD.
采用等电聚焦法测定了42例日本非家族性晚发型阿尔茨海默病（AD）患者及96例年龄匹配、无高脂血症和/或糖尿病的对照者的载脂蛋白E（apo E）表型。AD患者与对照者之间apo E表型分布存在显著差异（P < 0.0001）。这种差异主要归因于E4/3和E3/3表型的频率不同。在42例AD患者中有24例（57.1%）检测到apo E4/3表型，是96例对照者中9例（9.4%）的6倍多。相比之下，在各民族中最常见的apo E表型E3/3，仅在15例（35.7%）AD患者中检测到。这些结果表明apo E4同工蛋白与日本晚发型非家族性AD之间存在强关联，且apo E4是这类AD发生的一个可能危险因素。
