载脂蛋白E4与散发性阿尔茨海默病的关联在早发型中更为明显。

Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type.

作者信息

Dai X Y, Nanko S, Hattori M, Fukuda R, Nagata K, Isse K, Ueki A, Kazamatsuri H

机构信息

Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

Neurosci Lett. 1994 Jul 4;175(1-2):74-6. doi: 10.1016/0304-3940(94)91081-2.

DOI:10.1016/0304-3940(94)91081-2

PMID:7970216

Abstract

Apolipoprotein E genotypes in 88 unrelated Japanese patients with NINCDS-ADRDA sporadic Alzheimer's disease (AD) were examined and compared with those of 93 healthy controls. Frequency of epsilon 4 allele was increased in patients with AD (31%) compared with controls (10%), as was reported previously. Individuals homozygous or heterozygous for the allele epsilon 4 had a 5.9-fold increased risk of AD. This tendency was more pronounced in early onset sporadic (= non-familial) type than late onset type. The relative risk was also greater for early onset type (RR = 11.7; 95% CI, 4.9-28.3) than late onset type (RR = 4.3; 95% CI, 2.1-8.8). Moreover, patients with homozygote for the allele epsilon 4 had a 14.7-fold increased risk of early onset sporadic AD (P < 0.005, chi 2 = 9.0, df = 1, 95% CI, 2.5-85.1). Our findings indicated that association of apolipoprotein epsilon 4 with sporadic Alzheimer's disease is more pronounced in early onset type than in late onset type.

摘要

对88例无亲缘关系的日本NINCDS - ADRDA散发性阿尔茨海默病（AD）患者的载脂蛋白E基因型进行了检测，并与93名健康对照者的基因型进行比较。与之前报道的一样，AD患者中ε4等位基因的频率（31%）高于对照组（10%）。携带ε4等位基因的纯合子或杂合子个体患AD的风险增加了5.9倍。这种趋势在早发性散发性（即非家族性）类型中比晚发性类型中更为明显。早发性类型的相对风险（RR = 11.7；95% CI，4.9 - 28.3）也高于晚发性类型（RR = 4.3；95% CI，2.1 - 8.8）。此外，携带ε4等位基因纯合子的患者患早发性散发性AD的风险增加了14.7倍（P < 0.005，χ2 = 9.0，df = 1，95% CI，2.5 - 85.1）。我们的研究结果表明，载脂蛋白ε4与散发性阿尔茨海默病的关联在早发性类型中比晚发性类型中更为明显。