Suematsu M, Ohnishi T, Shinno E, Maeda S, Matsumoto K, Sakuda M, Saito K
Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Osaka University, Suita, Japan.
Neurosci Lett. 1993 Dec 12;163(2):193-6. doi: 10.1016/0304-3940(93)90380-4.
The effect of chronic exposure to clonidine or morphine on clonidine- and morphine-induced analgesia in mice was examined. Binding of L- or N-type calcium channel antagonist to cortical membrane fractions was also compared between these groups of mice. A decrease in the analgesic effect of clonidine and morphine was observed following prolonged administration of clonidine or morphine. Binding of [3H]PN 200-110, an L-type calcium channel antagonist, decreased following prolonged administration of clonidine whereas it increased after morphine treatment. On the other hand, a significant increase of [125I]omega-conotoxin, an N-type calcium channel antagonist, binding was observed after chronic clonidine or morphine treatment. These results will be discussed in relation with the possible development of cross-tolerance between clonidine and morphine through the change in calcium channels, more specifically in N-type channels.
研究了长期暴露于可乐定或吗啡对小鼠可乐定和吗啡诱导镇痛作用的影响。还比较了这些组小鼠中L型或N型钙通道拮抗剂与皮质膜组分的结合情况。长期给予可乐定或吗啡后，观察到可乐定和吗啡的镇痛作用降低。L型钙通道拮抗剂[3H]PN 200 - 110的结合在长期给予可乐定后减少，而在吗啡处理后增加。另一方面，长期给予可乐定或吗啡后，观察到N型钙通道拮抗剂[125I]ω-芋螺毒素的结合显著增加。将结合钙通道的变化，更具体地说是N型通道的变化，讨论这些结果与可乐定和吗啡之间可能产生交叉耐受性的关系。
