Saika S, Yamanaka O, Hashizume N, Kobata S, Okada Y, Uenoyama K, Ooshima A
Department of Ophthalmology, Wakayama Medical College, Japan.
Ophthalmic Res. 1993;25(6):363-70. doi: 10.1159/000267338.
Recruitment of keratocytes into injured corneal stroma, and secretion of proteins including collagen in the cells are essential for wound healing of the corneal stroma. We examined the effect of a proline analog, cis-hydroxyproline, on the adhesion, migration and growth of rabbit keratocytes in vitro. This agent decreased the plating efficiency, migration and growth of the keratocytes in a dose-dependent manner. Reduction in these cellular activities may reflect altered functions of pericellular proteins such as collagen. Further studies are needed to determine which specific protein is involved.
角膜细胞募集到受伤的角膜基质中，以及细胞中包括胶原蛋白在内的蛋白质分泌，对于角膜基质的伤口愈合至关重要。我们研究了脯氨酸类似物顺式羟脯氨酸对兔角膜细胞体外黏附、迁移和生长的影响。该试剂以剂量依赖的方式降低了角膜细胞的接种效率、迁移和生长。这些细胞活动的减少可能反映了细胞周围蛋白质（如胶原蛋白）功能的改变。需要进一步研究以确定涉及哪种特定蛋白质。
