[人类免疫缺陷病毒（HIV）对核苷类似物的耐药性是否表明应联合使用这些药物？]
[Is resistance of human immunodeficiency viruses (HIV) to nucleoside analogs an indication for their combined use?].
作者信息
Pépin J M, Simon F, Brun-Vezinet F
机构信息
Laboratoire de Virologie, Hôpital Bichat-Claude Bernard, Paris, France.
出版信息
Pathol Biol (Paris). 1993 Oct;41(8 Pt 2):788-93.
PMID:8309722
Abstract
HIV resistance to nucleoside analogues such as zidovudine (AZT) is to date a source of concern, even if its clinical significance is yet to be determined. Phenotypic and genotypic data concerning HIV resistance will be presented, then the potential benefits of nucleoside combinations will be discussed.
摘要
即使其临床意义尚待确定，但迄今为止，人类免疫缺陷病毒（HIV）对核苷类似物如齐多夫定（AZT）产生耐药性仍是一个令人担忧的问题。将展示有关HIV耐药性的表型和基因型数据，然后讨论核苷联合用药的潜在益处。
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