Escribano A, Armengot M, Marco V, Basterra J, Brines J
Department of Pediatrics, Valencia University Clinic, Spain.
Pediatr Pulmonol. 1993 Sep;16(3):167-9. doi: 10.1002/ppul.1950160306.
The diagnosis of primary ciliary dyskinesia (PCD) depends on electron microscopic examination of cilia obtained from mucosal biopsies of the nasal turbinates or the trachea. This is an invasive, time-consuming, and expensive technique. The low incidence of this abnormality, the large number of infants and children with suggestive symptoms, and the lack of a reliable screening test make the decision to proceed with diagnostic biopsy a common problem in recurrent or chronic respiratory pediatric conditions. To improve this situation early in infancy, nasal mucociliary transport was evaluated in 10 normal newborns using the Tc-99m-labeled seroalbumin technique, and the results obtained were compared with those corresponding to a newborn with Kartagener's syndrome. Transport velocity in normal newborns was similar to that observed in older children and in adults, in contrast to the tracer immobility seen in the affected newborn. This technique is simple, safe, objective, and well tolerated in this age group and might be used as an early screening test to ruling out PCD.
原发性纤毛运动障碍（PCD）的诊断依赖于对取自鼻甲或气管黏膜活检组织的纤毛进行电子显微镜检查。这是一种侵入性、耗时且昂贵的技术。这种异常情况发病率低，有提示性症状的婴幼儿数量众多，且缺乏可靠的筛查试验，因此在儿科复发性或慢性呼吸道疾病中，决定是否进行诊断性活检是一个常见问题。为了在婴儿早期改善这种情况，使用锝-99m标记的血清白蛋白技术对10名正常新生儿的鼻黏液纤毛运输进行了评估，并将所得结果与一名患有卡塔格内综合征的新生儿的结果进行了比较。正常新生儿的运输速度与大龄儿童及成人中观察到的相似，这与患病新生儿中示踪剂不动的情况形成对比。该技术简单、安全、客观，且在这个年龄组中耐受性良好，可作为排除PCD的早期筛查试验。
