Widmark A, Damber J E, Bergh A, Henriksson R
Department of Oncology, University of Umeå, Sweden.
Prostate. 1994;24(2):79-83. doi: 10.1002/pros.2990240205.
The present study was designed to determine if estramustine phosphate (EMP) could potentiate the effects of irradiation on the Dunning (R3327) prostatic adenocarcinoma in rats. Two groups of male Copenhagen x Fisher F1 rats carrying bilateral tumors in the flank were used. Irradiation was given with a linear accelerator 6 MV, in a dose of 6 Gy/day for 4 days to the tumor on one side while the tumor on the other side served as control. EMP (360 micrograms/24 hours) was administered with osmotic pumps to one group of rats for 2 weeks, starting 1 week before irradiation. Tumor growth was calculated by measuring tumor volume, and tumor blood flow was measured 8 weeks after treatment. Irradiation alone effectively delayed tumor growth and EMP enhanced these effects. Tumor blood flow was stimulated by EMP treatment irrespective of radiotherapy. Volume density of tumor epithelium was effectively decreased by irradiation but no significant effects could be seen after EMP. In conclusion, the present study shows that EMP potentiates irradiation on rat prostatic adenocarcinoma, and further evaluation of this therapeutic approach in the clinical treatment of prostatic carcinoma is thus justified.
本研究旨在确定磷酸雌莫司汀（EMP）是否能增强辐射对大鼠邓宁（R3327）前列腺腺癌的作用。使用了两组在胁腹携带双侧肿瘤的雄性哥本哈根×费希尔F1大鼠。用直线加速器以6兆伏的能量进行照射，对一侧肿瘤给予6 Gy/天的剂量，持续4天，而另一侧肿瘤作为对照。从照射前1周开始，用渗透泵对一组大鼠给药EMP（360微克/24小时），持续2周。通过测量肿瘤体积计算肿瘤生长情况，并在治疗8周后测量肿瘤血流。单独照射有效地延迟了肿瘤生长，EMP增强了这些作用。无论是否进行放疗，EMP治疗均可刺激肿瘤血流。照射可有效降低肿瘤上皮的体积密度，但EMP治疗后未见明显效果。总之，本研究表明EMP可增强辐射对大鼠前列腺腺癌的作用，因此有理由对这种治疗方法在前列腺癌临床治疗中的应用进行进一步评估。
