Selective D1 and D2 dopamine receptor antagonists produce differential effects on reaction time in the rat.

The purpose of this investigation was to determine whether selectively blocking D1 and D2 dopamine receptors produces a differential effect on the characteristics (speed and success) of the reaction time response in rats. Animals were shaped to release a lever in response to an auditory/visual stimulus to avoid mild foot shock. The selective D1 antagonist SCH 23390 (0, 70, and 100 micrograms/kg, IP) and the selective D2 antagonists spiperone (0, 1, and 10 micrograms/kg, IP) and haloperidol (0, 10, and 100 micrograms/kg, IP) were studied for their effects on successful avoidance and response latency. SCH 23390 impaired successful avoidance and increased response latencies in a dose-dependent manner. Spiperone and haloperidol also produced dose-related decreases in successful avoidance. In contrast to the dose-related increase in response latencies produced by SCH 23990, 1 microgram/kg spiperone and 10 micrograms/kg haloperidol significantly decreased the latencies of successful responses. Spiperone (10 micrograms/kg) had little effect on response latencies, while 100 micrograms/kg haloperidol increased them. The results of these experiments demonstrate that reaction time is differentially affected by selective dopamine receptor blockade and that the speed and success of reaction time responses can be independently modulated by D1 vs. D2 receptor activity.