同时进行急性运动可改变对毒扁豆碱的中枢和外周反应。

Concurrent acute exercise alters central and peripheral responses to physostigmine.

作者信息

Dube S N, Somani S M, Babu S R

机构信息

Southern Illinois University, School of Medicine, Department of Pharmacology, Springfield 62794-9230.

出版信息

Pharmacol Biochem Behav. 1993 Dec;46(4):827-34. doi: 10.1016/0091-3057(93)90208-b.

DOI:10.1016/0091-3057(93)90208-b

PMID:8309962

Abstract

This study reports the modulatory effects of physostigmine (Phy) and concurrent acute exercise on the time course of cholinesterase (ChE) activity, the rate of decarbamylation (Kd), and half-time of recovery of ChE in red blood cells (RBC) and various tissues of rats. Acute exercise equivalent to 80% VO2-max (maximal oxygen consumption) transiently increased the RBC ChE activity, whereas Phy decreased ChE activity in RBC and various tissues. Physostigmine along with concurrent acute exercise increased the Kd in RBC, brain, and heart by 56.4%, 66.7%, and 139%, respectively, compared to Phy alone. The Kd in diaphragm and muscle decreased to 14.1% and 56.2%, respectively, compared to Phy alone. The variation in Kd might be due to the effect of concurrent acute exercise on the redistribution of Phy in various tissues of rat as a result of changes in blood flow.

摘要

本研究报告了毒扁豆碱（Phy）以及同时进行的急性运动对大鼠红细胞（RBC）和各种组织中胆碱酯酶（ChE）活性的时程、脱氨甲酰化速率（Kd）和ChE恢复半衰期的调节作用。相当于80%最大摄氧量（VO2-max）的急性运动可使红细胞ChE活性短暂增加，而毒扁豆碱可降低红细胞和各种组织中的ChE活性。与单独使用毒扁豆碱相比，毒扁豆碱与同时进行的急性运动使红细胞、脑和心脏中的Kd分别增加了56.4%、66.7%和139%。与单独使用毒扁豆碱相比，膈肌和肌肉中的Kd分别降至14.1%和56.2%。Kd的变化可能是由于同时进行的急性运动因血流变化而对毒扁豆碱在大鼠各种组织中的重新分布产生影响所致。