Lun A, Berndt C, Gross J, Fischer H D, Bergsträsser E, Scheller D
Institute of Pathological and Clinical Biochemistry, Humboldt University, Medical Faculty (Charité), Berlin, Germany.
Pharmacol Biochem Behav. 1993 Dec;46(4):867-71. doi: 10.1016/0091-3057(93)90215-f.
Long-term changes of learning behavior and of the striatal dopaminergic system were observed in a rat model of early postnatal hypoxia. Striatal dopamine (DA) concentration, K(+)-stimulated DA release from slices, and DA uptake into crude synaptosomal preparations (S1 fractions) were used as markers of the striatal DAergic system. Active avoidance learning was tested as behavioral criterion. Cyclodextrin and flunarizine were found to produce long-term effects on the DAergic system in control animals. While cyclodextrin normalized hypoxia-induced effects in DA release, flunarizine prevented those in DA uptake and improved avoidance learning.
在新生大鼠早期缺氧模型中观察到学习行为和纹状体多巴胺能系统的长期变化。纹状体多巴胺（DA）浓度、切片中K(+)刺激的DA释放以及粗制突触体制剂（S1组分）对DA的摄取被用作纹状体DA能系统的标志物。主动回避学习作为行为标准进行测试。发现环糊精和氟桂利嗪对对照动物的DA能系统产生长期影响。虽然环糊精使缺氧诱导的DA释放效应恢复正常，但氟桂利嗪阻止了DA摄取方面的效应并改善了回避学习。
