Najim R A, Clor K M
Department of Pharmacology, College of Medicine, University of Baghdad, Iraq.
Pharmacol Biochem Behav. 1993 Dec;46(4):995-7. doi: 10.1016/0091-3057(93)90234-k.
The possibility that benzodiazepine-induced hyperglycaemia is mediated through the release of endogenous endorphins was tested. The results show that naloxone, the opiate antagonist, potentiated clonazepam-induced hyperglycaemia. Treatment with increasing doses of morphine for six days, which induced tolerance to endorphins, did not affect clonazepam-induced hyperglycaemia. The results indicate that endorphins do not mediate benzodiazepine-induced hyperglycaemia.
对苯二氮卓类药物诱导的高血糖症是否通过内源性内啡肽的释放介导进行了测试。结果表明，阿片拮抗剂纳洛酮增强了氯硝西泮诱导的高血糖症。连续六天用递增剂量的吗啡治疗，诱导对内啡肽产生耐受性，但这并未影响氯硝西泮诱导的高血糖症。结果表明，内啡肽并不介导苯二氮卓类药物诱导的高血糖症。
