[The prognostic significance of pre-existing lymphocytotoxic antibodies in cadaveric kidney allografts with a negative specific crossmatch].

The paper presents the results obtained on preexisting lymphocytotoxic antibodies in 110 patients with the use of cryopreserved donor lymphocytes. Preexisting antibodies (PA) are shown to display in 52% of primary patients in the nephrological department. Follow-up measurements gave evidence on PA levels fluctuations following an undulating form. The analysis of the transplants 3-month survival in the negative cross-match indicated a better prognosis in those patients who showed antibodies to none of the donors. The presence of lymphocytotoxic reactions even of nondonor specificity, on the contrary, made the prognosis much worse.