Taylor S M, Kenny J, Houston A, Hewitt S A
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast.
Vet Rec. 1993 Nov 20;133(21):519-21. doi: 10.1136/vr.133.21.519.
Laying broiler breeder hens infected with Capillaria obsignata were treated with in-feed fenbendazole either at a dose of 30 ppm for six days or 80 ppm for three days. The respective efficacies of treatment were 92.3 and 99.3 per cent. These results were a reflection of the plasma pharmacokinetics of fenbendazole and its metabolites in the regimens, which showed that the detectable plasma concentrations of the anthelmintically active fenbendazole sulphoxide in the second treatment were significantly greater than the first, with the area under the curve 1.34 times that of treatment 1. Both treatments produced a slight decline in egg production, but only the loss in production with treatment 1 was significant. Hatchability of eggs with both treatments was not significantly affected.
给感染了隐匿毛细线虫的肉种鸡在饲料中添加芬苯达唑进行治疗，剂量为30 ppm，持续6天，或80 ppm，持续3天。相应的治疗效果分别为92.3%和99.3%。这些结果反映了芬苯达唑及其代谢产物在这些给药方案中的血浆药代动力学情况，结果表明，第二次治疗中具有驱虫活性的芬苯达唑亚砜在血浆中的可检测浓度显著高于第一次治疗，曲线下面积是第一次治疗的1.34倍。两种治疗方法均使产蛋量略有下降，但只有第一次治疗导致的产蛋量损失具有显著性。两种治疗方法对种蛋孵化率均无显著影响。
