Kendal A P, Schieble J, Cooney M K, Chin J, Foy H M, Noble G R
Am J Epidemiol. 1978 Oct;108(4):308-11. doi: 10.1093/oxfordjournals.aje.a112624.
From March through June 1977 a total of 31 influenza A (H3N2) viruses were isolated from students with respiratory disease who were seen at the student health service on the Berkeley campus of the University of California, and 32 influenza A (H3N2) viruses were isolated from persons who participated in a city-wide febrile respiratory disease surveillance program in Seattle. The antigenic specificity of the hemagglutinin was determined for each isolate by hemagglutination inhibition testing with sera from ferrets infected with prototype strains A/Victoria/3/75 and A/Texas/1/77. In each of the three months, April, May and June, A/Victoria/3/75-like and A/Texas/1/77-like viruses were identified among isolates from both communities, and the numbers of isolates of the two antigenic variants from patients seen with influenza-like illnesses were similar. The findings emphasize the need to examine multiple isolates even from within single communities to determine the antigenic specificity of current strains of influenza virus.
1977年3月至6月期间，从加利福尼亚大学伯克利分校学生健康服务中心就诊的呼吸道疾病学生中总共分离出31株甲型流感（H3N2）病毒，并且从参与西雅图全市发热呼吸道疾病监测项目的人员中分离出32株甲型流感（H3N2）病毒。通过用感染了原型毒株A/维多利亚/3/75和A/得克萨斯/1/77的雪貂血清进行血凝抑制试验，确定了每株分离株血凝素的抗原特异性。在4月、5月和6月这三个月中的每个月，在两个社区的分离株中都鉴定出了A/维多利亚/3/75样和A/得克萨斯/1/77样病毒，并且从患流感样疾病的患者中分离出的两种抗原变体的数量相似。这些发现强调，即使是从单个社区内也需要检测多个分离株，以确定当前流感病毒株的抗原特异性。
