Mohr W
Abt. Pathologie, Universität Ulm.
Z Orthop Ihre Grenzgeb. 1993 Nov-Dec;131(6):477-82. doi: 10.1055/s-2008-1040057.
The morphological changes in human osteoarthrosis are compared with those occurring in the ankle joints of old rats. Chondrocytic necrosis, proteoglycan loss, cartilage fibrillation and loss of cartilage and bone are similar in both species. It is concluded that osteoarthrosis of the ankle joints in old rats may be a model to study the mechanisms leading to cartilage destruction. In contrast to the process in rats the human disease is "complicated" by secondary events as ischemic bone necrosis and debris synovitis. The latter two processes are of importance for the understanding of the clinical symptoms of osteoarthrotic joints.
将人类骨关节炎的形态学变化与老年大鼠踝关节的变化进行比较。两种物种的软骨细胞坏死、蛋白聚糖丢失、软骨纤维化以及软骨和骨的丢失情况相似。得出结论，老年大鼠踝关节骨关节炎可能是研究导致软骨破坏机制的模型。与大鼠的过程不同，人类疾病因缺血性骨坏死和碎屑滑膜炎等继发性事件而“复杂化”。后两个过程对于理解骨关节炎关节的临床症状很重要。
