Gizaris V, Roumeliotou A, Ktenas E, Papoutsakis G, Papaevangelou G
Nursing School, University of Athens.
Vaccine. 1993 Nov;11(14):1445-7. doi: 10.1016/0264-410x(93)90175-w.
The immunogenicities of hepatitis B virus vaccines containing S and pre-S2 regions were compared using two different schedules of immunization (A: 0-1-2-12 months and B: 0-1-6 months). Two hundred males and females aged 17-22 years were vaccinated with 20 micrograms per dose. The follow-up period was extended up to 13 months. One month after the booster dose anti-HBs were detected in 98.9% of those vaccinated with schedule A and 100% of those vaccinated with schedule B. Geometric mean titres (GMT) of anti-HBs were significantly higher with schedule A than schedule B, reaching GMT of 16269.7 mIU ml-1 and 4372.4 mIU ml-1, respectively, one month after the booster dose. Seroconversion rates for the anti-pre-S2 antibodies one month after the booster dose were 89.4% for schedule A and 76.6% for schedule B. GMT were 157.8 mIU ml-1 and 67.5 mIU ml-1, respectively. We conclude that both vaccines elicit high titres of anti-HBs and anti-pre-S2 antibodies. Immunity lasts longer in schedule A than in schedule B.
采用两种不同的免疫程序（A：0-1-2-12月和B：0-1-6月）比较了含S和前S2区的乙肝疫苗的免疫原性。200名年龄在17-22岁的男性和女性接种了每剂20微克的疫苗。随访期延长至13个月。加强剂量接种后1个月，采用程序A接种的人群中98.9%检测到抗-HBs，采用程序B接种的人群中100%检测到抗-HBs。加强剂量接种后1个月，程序A的抗-HBs几何平均滴度（GMT）显著高于程序B，分别达到16269.7 mIU/ml和4372.4 mIU/ml。加强剂量接种后1个月，程序A的抗前S2抗体血清转化率为89.4%，程序B为76.6%。GMT分别为157.8 mIU/ml和67.5 mIU/ml。我们得出结论，两种疫苗均能诱导产生高滴度的抗-HBs和抗前S2抗体。程序A的免疫持续时间比程序B长。
