Robertson C
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Acta Neurochir Suppl (Wien). 1993;59:25-7. doi: 10.1007/978-3-7091-9302-0_4.
Global cerebral blood flow (CBF) was measured serially for up to 10 days after severe head injury, and related to outcome. Twenty-five of the patients had a reduced CBF, 47 had a normal CBF, and 30 had an elevated CBF. Patients with a reduced CBF had a poorer outcome than patients with a normal or elevated CBF. There were no differences in the type of injury, initial GCS, severity of intracranial hypertension in each CBF group. Systemic factors did not significantly contribute to the differences in CBF among the 3 groups. A logistic regression model of the effect of CBF on neurological outcome was developed. When adjusted of variables which were found to be significant confounders, including age, initial Glasgow Coma Score, hemoglobin, cerebral perfusion pressure, and cerebral oxygen consumption, a reduced CBF remained significantly associated with an unfavorable neurological outcome.
在严重颅脑损伤后连续10天测量全脑血流量（CBF），并将其与预后相关联。25例患者CBF降低，47例CBF正常，30例CBF升高。CBF降低的患者比CBF正常或升高的患者预后更差。各CBF组在损伤类型、初始格拉斯哥昏迷量表（GCS）、颅内高压严重程度方面无差异。全身因素对三组间CBF的差异无显著影响。建立了CBF对神经功能预后影响的逻辑回归模型。当对包括年龄、初始格拉斯哥昏迷评分、血红蛋白、脑灌注压和脑氧消耗等被发现为显著混杂因素的变量进行校正后，CBF降低仍与不良神经功能预后显著相关。
