Haberl R L, Villringer A, Dirnagl U
Department of Neurology, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.
Acta Neurochir Suppl (Wien). 1993;59:64-8. doi: 10.1007/978-3-7091-9302-0_11.
Laser Doppler flowmetry (LDF) is a technique for real-time assessment of cerebral blood flow (CBF) changes with potential clinical applicability. Experimental studies have validated that LDF allows accurate measurement of changes in CBF due to physiological and pathophysiological stimuli. Absolute quantitation of flow in ml/100 g min by LDF is not possible. The technique may be used in patients during open brain surgery and postoperatively for bedside CBF monitoring. Disadvantages of the technique are that the flow measurement is highly localized (about 1 mm3) and artifacts may be produced by movement, light or probe placement over large surface vessels. The fibre optic probes for LDF are small enough to be introduced into routinely used intraventricular pressure catheters. We suggest that simultaneous monitoring of CBF and intracranial pressure by such a device holds promise for improved management of patients with critical brain injury.
激光多普勒血流仪（LDF）是一种用于实时评估脑血流（CBF）变化的技术，具有潜在的临床应用价值。实验研究证实，LDF能够准确测量由于生理和病理生理刺激引起的CBF变化。无法通过LDF以毫升/100克·分钟为单位进行血流的绝对定量。该技术可用于开颅手术期间及术后的患者，以进行床边CBF监测。该技术的缺点是血流测量高度局限（约1立方毫米），并且移动、光线或探头放置在大的表面血管上可能会产生伪影。用于LDF的光纤探头足够小，可以插入常规使用的脑室内压导管中。我们认为，通过这样一种设备同时监测CBF和颅内压有望改善对重症脑损伤患者的管理。
