Steinmeier R, Bondar I, Bauhuf C
Department of Neurosurgery, University of Erlangen-Nünberg, Federal Republic of Germany.
Acta Neurochir Suppl (Wien). 1993;59:69-73. doi: 10.1007/978-3-7091-9302-0_12.
Preliminary observations of laser Doppler flowmetry (LDF) signal changes in comatose patients with severe head injury or higher grade subarachnoid haemorrhage are presented. The data demonstrate that LDF measurements by no means lend themselves to a straightforward and unequivocal interpretation. Three main sources of LDF signal "bias" are tentatively distinguished: (1) properties inherent to the LDF measurement system and (2) spatial as well as (3) temporal heterogeneity of functional responses of the cerebral microvascular bed lead to unexpected, unpredictable and seemingly "paradox" patterns of the LDF signals. Despite the exploratory character of our data, we are convinced that they strongly suggest a more critical and cautious appraisal of the present possibilities of LDF in monitoring comatose patients than suggested by several other recent reports on this topic.
本文介绍了对重度颅脑损伤或高级别蛛网膜下腔出血昏迷患者激光多普勒血流仪（LDF）信号变化的初步观察结果。数据表明，LDF测量绝不能简单直接且明确无误地进行解读。初步区分出LDF信号“偏差”的三个主要来源：（1）LDF测量系统固有的特性，（2）空间因素，以及（3）脑微血管床功能反应的时间异质性，这些都会导致LDF信号出现意想不到、不可预测且看似“矛盾”的模式。尽管我们的数据具有探索性质，但我们坚信，与近期其他几篇关于该主题的报告相比，这些数据强烈表明，在监测昏迷患者时，对LDF目前的应用可能性需要进行更审慎和谨慎的评估。
