Smith K J, Skelton H G, Holland T T, Morgan A M, Lupton G P
Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, D.C. 20306.
Am J Dermatopathol. 1993 Dec;15(6):528-33. doi: 10.1097/00000372-199312000-00002.
We present 11 cases of primary neuroendocrine (Merkel cell) carcinoma of the skin with an intraepidermal component that were identified in a larger review of Merkel cell carcinomas. Among these is a case with a follow-up of over 11 years in which the primary lesion appeared as bowenoid dysplasia, with subsequent recurrences as intraepidermal Merkel cell carcinoma with focal tubular differentiation, and then with dermal invasion and lymph node metastasis. In addition to immunohistochemical markers commonly used in the identification of Merkel cell carcinomas (neuron-specific enolase and cytokeratin), these tumors stained with Ber-EP4, an immunohistochemical marker used to identify carcinomas. We believe that these histopathologic and immunohistochemical features further confirm that Merkel cell carcinomas represent an epithelial tumor with the potential for neuroendocrine and adnexal differentiation.
我们在对默克尔细胞癌进行的一项规模更大的回顾研究中，发现了11例伴有表皮内成分的原发性皮肤神经内分泌（默克尔细胞）癌。其中1例随访超过11年，其原发损害表现为鲍温样发育异常，随后复发为具有局灶性管状分化的表皮内默克尔细胞癌，继而出现真皮浸润和淋巴结转移。除了常用于鉴别默克尔细胞癌的免疫组化标志物（神经元特异性烯醇化酶和细胞角蛋白）外，这些肿瘤还可被Ber-EP4染色，Ber-EP4是一种用于鉴别癌的免疫组化标志物。我们认为，这些组织病理学和免疫组化特征进一步证实，默克尔细胞癌是一种具有神经内分泌和附属器分化潜能的上皮性肿瘤。
