Ribet M, Dambron P
Clinique Chirurgicale Ouest, Hôpital Calmette, CHU, Lille.
Ann Chir. 1993;47(8):721-8.
Sixty-six cases of multiple primary lung cancers were classified into 18 synchronous cancers and 48 metachronous cancers. They all occurred in tobacco-smoking men. The first group were symptomatic in 66% of cases, the second were symptomatic in 40% of cases. Six synchronous locations were unilateral and 12 were bilateral; 19 metachronous locations were ipsilateral and 29 were contralateral. Two cases had a third metachronous cancer. The resections of both tumours were performed in 11 out of 18 cases of synchronous cancers and 15 out of 48 cases of metachronous cancers. There were 2 deaths related to metachronous cancers. No patient with synchronous cancers survived 5 years after resection. One third of patients survived 5 years after resection of a metachronous cancer. Synchronous cancers represent an advanced stage. Metachronous cancers are diagnosed too late.
66例多原发性肺癌被分为18例同时性癌和48例异时性癌。它们均发生于吸烟男性。第一组66%的病例有症状，第二组40%的病例有症状。6例同时性癌位于单侧，12例位于双侧；19例异时性癌位于同侧，29例位于对侧。2例有第三次异时性癌。18例同时性癌中有11例、48例异时性癌中有15例进行了双肿瘤切除。有2例死亡与异时性癌相关。同时性癌切除术后无患者存活5年。三分之一的患者在异时性癌切除术后存活5年。同时性癌代表晚期。异时性癌诊断过晚。
