Louagie Y A, Haxhe J P, Buche M, Schoevaerdts J C
Division of Cardiovascular and Thoracic Surgery, University Hospital of Mont-Godinne (Catholic University of Louvain), Yvoir, Belgium.
Ann Thorac Surg. 1994 Feb;57(2):357-64. doi: 10.1016/0003-4975(94)90997-0.
This study attempts to relate flow findings in internal mammary (IMA) and saphenous vein coronary artery bypass grafts to postoperative outcome. From 262 patients undergoing coronary artery bypass grafting, 601 electromagnetic flow measurements were obtained in IMA and saphenous vein grafts, and free graft flow was measured in 227 IMAs prior to grafting. Retrograde flushing of the IMA with diluted papaverine hydrochloride resulted in a marked increase in IMA free flow (124 +/- 4 mL/min versus 66 +/- 5 mL/min; p < 0.001). However, IMA free flow did not correlate with electromagnetic flow measurements after grafting to the left anterior descending coronary artery. The use of IMAs with free flows lower than 50 mL/min did not affect clinical outcome. Flow measured in saphenous vein grafts (66 +/- 9 mL/min) with an electromagnetic flowmeter was significantly greater (p < 0.001) than that in the IMA grafted on the left anterior descending coronary artery (36 +/- 3 mL/min) under comparable hemodynamic conditions. For the purpose of data analysis, patients were separated into three groups based on increasing incidence of complications: levels 0, 1, and 2. Patients with an uneventful outcome had a mean graft flow at chest closure of 51 +/- 3 mL/min versus 51 +/- 4 mL/min for patients in complication level 1 and 45 +/- 11 mL/min for patients in complication level 2 (p = not significant). Free flow measured in a vasodilated IMA was a poor predictor of flow into a grafted IMA and did not affect clinical outcome. We were unable to validate any flow limit to use of the IMA.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究试图将乳内动脉(IMA)和大隐静脉冠状动脉旁路移植术中的血流情况与术后结果相关联。在262例行冠状动脉旁路移植术的患者中,对IMA和大隐静脉移植物进行了601次电磁血流测量,并在227支IMA移植前测量了其游离血流。用稀释的盐酸罂粟碱对IMA进行逆行冲洗,导致IMA游离血流显著增加(124±4 mL/分钟对66±5 mL/分钟;p<0.001)。然而,IMA游离血流与移植至左前降支冠状动脉后的电磁血流测量值并无相关性。使用游离血流低于50 mL/分钟的IMA并不影响临床结果。在可比的血流动力学条件下,用电磁流量计测得的大隐静脉移植物血流(66±9 mL/分钟)显著高于移植至左前降支冠状动脉的IMA血流(36±3 mL/分钟)(p<0.001)。为了进行数据分析,根据并发症发生率的增加将患者分为三组:0级、1级和2级。预后良好的患者在关胸时的平均移植物血流为51±3 mL/分钟,而并发症1级患者为51±4 mL/分钟,并发症2级患者为45±11 mL/分钟(p无显著性差异)。血管扩张的IMA中测得的游离血流对移植至IMA的血流预测性较差,且不影响临床结果。我们无法验证IMA使用的任何血流限制。(摘要截选至250字)