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[艾滋病中的杆菌性紫癜。2例病例的解剖临床研究]

[Bacillary peliosis in AIDS. Anatomo-clinical study of 2 cases].

作者信息

Mainguene C, Moreau A, Hofman P, Milpied-Homsi B, Roulot D, Marullo S, Clauvel J P, Lenne Y, Amouroux J

机构信息

Service d'Anatomie Pathologique, Hôpital Avicenne, Bobigny.

出版信息

Ann Pathol. 1993;13(5):341-5.

PMID:8311862
Abstract

The authors report two cases of peliosis hepatis, occurring in patients with AIDS, who presented a persistent fever and an hepatomegaly. The liver biopsies showed areas of peliosis, where bacilli were observed by Warthin-Starry stain. In one case, techniques of molecular biology allowed the identification of Rochalimaea henselae, pathogen involved in bacillary angiomatosis. This rickettsia has been newly recognized in the United-States, where 17 cases of bacillary peliosis have been published in immunocompromised hosts and mainly in patients with AIDS. These observations illustrate the clinical and histological features of this new opportunistic infection, as it is described in the literature. The clinical signs include an unexplained fever, an hepatomegaly, and in 75% of the cases, a splenomegaly. The cutaneous lesions of bacillary angiomatosis are associated in 40% of the cases. An antibiotic treatment by erythromycin ensures a complete recovery.

摘要

作者报告了两例肝紫癜病病例,发生在艾滋病患者中,这些患者持续发热且肝肿大。肝脏活检显示有肝紫癜区域,经沃辛 - 斯塔里染色观察到杆菌。在一例中,分子生物学技术鉴定出汉赛巴尔通体,这是一种与杆菌性血管瘤病有关的病原体。这种立克次体在美国最近才被认识到,在免疫功能低下宿主中已发表了17例杆菌性肝紫癜病例,主要是艾滋病患者。这些观察结果说明了这种新的机会性感染的临床和组织学特征,正如文献中所描述的那样。临床体征包括不明原因发热、肝肿大,75%的病例有脾肿大。40%的病例伴有杆菌性血管瘤病的皮肤损害。用红霉素进行抗生素治疗可确保完全康复。

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