胸腺肌细胞带有乙酰胆碱受体：与重症肌无力的可能关系。
Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis.
作者信息
Kao I, Drachman D B
出版信息
Science. 1977 Jan 7;195(4273):74-5. doi: 10.1126/science.831257.
PMID:831257
Abstract
Culture of dissociated thymus from rats and humans yielded cells identical to skeletal muscle with respect to morphology, contractility, electrophysiological properties, and the presence of acetylcholine receptors. These cells, strategically located in the thymus, may play a role in initiation of the autoimmune response against acetylcholine receptors, which is characteristic of myasthenia gravis.
摘要
对大鼠和人类的离体胸腺进行培养，所获得的细胞在形态、收缩性、电生理特性以及乙酰胆碱受体的存在方面与骨骼肌细胞相同。这些细胞在胸腺中所处位置关键，可能在引发针对乙酰胆碱受体的自身免疫反应中发挥作用，而这种自身免疫反应是重症肌无力的特征。
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