Tsuchiya T, Yoshida T, Imaeda A, Sakushima M, Kiho T, Ukai S
Gifu Prefectural Hospital, Japan.
Biol Pharm Bull. 1993 Nov;16(11):1111-3. doi: 10.1248/bpb.16.1111.
The effect of carbohydrate sulfate salts on the absorption and excretion of the herbicide, paraquat dichloride (PQ), was investigated in rats. A mixture of PQ and sodium dextran sulfate (DS) or sodium glucose sulfate (GS) was given orally to rats and then feces and urine were collected daily for 14 d. The cumulative amount of PQ excreted in the feces of rats given the mixture PQ and DS, or PQ and GS was 82.6% and 76.7% respectively. When PQ alone was administered, 56.7% was excreted in feces. Most (nearly 90%) of the PQ detected in feces was excreted within the first 24 h of the 14 d period in each case. The cumulative amount of PQ excreted in the urine over the 14 d period was 1.2% for the mixture PQ and DS and 0.7% for the mixture PQ and GS. When PQ was given alone the corresponding figure was 7.2%. In addition, the effect of DS and GS on PQ absorption from the rat small intestine was investigated using an in situ recirculating perfusion method. During 180 min period of recirculating perfusion, using PQ alone in normal saline, 13.4% of the herbicide was absorbed from the intestine. However, when the mixture of PQ and DS (or PQ and GS) in saline was used, the absorption was 3.9% for PQ-DS, of 4.8% for PQ-GS. Furthermore, an association of PQ with DS, or GS, was observed using gel filtration of the mixture of PQ-DS and PQ-GS in saline solution.(ABSTRACT TRUNCATED AT 250 WORDS)
在大鼠中研究了硫酸碳水化合物盐对除草剂百草枯二氯化物（PQ）吸收和排泄的影响。将PQ与硫酸葡聚糖钠（DS）或硫酸葡萄糖钠（GS）的混合物口服给予大鼠，然后连续14天每天收集粪便和尿液。给予PQ与DS或PQ与GS混合物的大鼠粪便中PQ的累积排泄量分别为82.6%和76.7%。单独给予PQ时，56.7%经粪便排泄。在每种情况下，粪便中检测到的大部分（近90%）PQ在14天周期的头24小时内排泄。14天期间尿液中PQ的累积排泄量，PQ与DS混合物为1.2%，PQ与GS混合物为0.7%。单独给予PQ时相应数字为7.2%。此外，使用原位循环灌注法研究了DS和GS对大鼠小肠吸收PQ的影响。在180分钟的循环灌注期间，在生理盐水中单独使用PQ时，13.4%的除草剂从小肠吸收。然而，当使用生理盐水与PQ和DS（或PQ和GS）的混合物时，PQ-DS的吸收为3.9%，PQ-GS的吸收为4.8%。此外，通过对生理盐水中PQ-DS和PQ-GS混合物进行凝胶过滤，观察到PQ与DS或GS之间存在关联。（摘要截断于250字）
