Wasserman K
Division of Respiratory and Critical Care, Physiology and Medicine, Harbor-UCLA Medical Center, Torrance 90509.
Monaldi Arch Chest Dis. 1993 Oct;48(5):509-14.
Breathing 100% O2 is a way of slowing breathing rate, decompressing hyperinflated, low VA/Q lung units, reducing the FRC and allowing the patient with COPD in acute respiratory failure to breath at a more comfortable lung volume and with a higher tidal volume. This should also improve the efficiency of breathing, increasing the fractional turnover of alveolar gas. Simultaneously O2 protects the brain, heart and other organs from hypoxic injury. Breathing 100% O2 provides the major therapeutic approach for rapidly reversing the pathophysiological cycle of impaired respiratory mechanics which threatens the life of the patient in acute respiratory failure. It is a therapeutic approach which might be employed in the tachypnoeic patient in acute respiratory distress, before initiating airway intubation and mechanical ventilation. This provides the physician with time to allow other mechanisms of bronchodilating the patient to be started, and for the need of a more aggressive approach to airway management to be evaluated.
吸入100%的氧气是一种减缓呼吸频率、使过度充气且通气/血流比值低的肺单位减压、降低功能残气量，并让急性呼吸衰竭的慢性阻塞性肺疾病（COPD）患者能够在更舒适的肺容积下以更大潮气量呼吸的方法。这还应能提高呼吸效率，增加肺泡气体的分数周转率。同时，氧气可保护大脑、心脏和其他器官免受缺氧损伤。吸入100%的氧气是迅速逆转威胁急性呼吸衰竭患者生命的呼吸力学受损病理生理循环的主要治疗方法。这是一种可在急性呼吸窘迫的呼吸急促患者中，在进行气道插管和机械通气之前采用的治疗方法。这为医生提供了时间，以便启动患者的其他支气管扩张机制，并评估是否需要采取更积极的气道管理方法。
