Wernicke M, Bazan G E
Surg Gynecol Obstet. 1977 Jan;144(1):45-6.
Quantitative morphologic assessment of immunoreactivity in regional lymph nodes in 82 patients with carcinoma of the breast without axillary node metastasis showed a significant decrease of the hyperplasia index with age. These differences were particularly noteworthy when premenopausal and postmenopausal women were compared, p less than 0.05. This finding might be an indication of a direct link between ovarian hormones, probably progesterone, and immunity, and it would challenge the concept of oophorectomy performed as a prophylactic measure in patients in the premenopausal period.
对82例无腋窝淋巴结转移的乳腺癌患者区域淋巴结免疫反应性进行的定量形态学评估显示，增生指数随年龄显著降低。绝经前和绝经后女性相比时，这些差异尤为显著，p值小于0.05。这一发现可能表明卵巢激素（可能是孕酮）与免疫之间存在直接联系，并且这将对绝经前期患者作为预防措施进行卵巢切除术的观念提出挑战。
