伴随大鼠蓝斑神经元DSP - 4损伤的电生理变化。
Electrophysiological changes accompanying DSP-4 lesions of rat locus coeruleus neurons.
作者信息
Magnuson D S, Staines W A, Marshall K C
机构信息
Department of Physiology, University of Ottawa, Ont., Canada.
出版信息
Brain Res. 1993 Nov 19;628(1-2):317-20. doi: 10.1016/0006-8993(93)90972-p.
The electrophysiological characteristics of intracellularly recorded locus coeruleus (LC) neurons in brain stem slices from DSP-4 treated animals have been compared to those from untreated controls. LC neurons from DSP-4 treated animals had action potentials and Ca2+ spikes (elicited in the presence of TTX) of significantly reduced duration compared to controls. These observations suggest that chemical axotomy with DSP-4 reduces Ca2+ conductance in neurons of the locus coeruleus.
已将经DSP-4处理的动物脑干切片中细胞内记录的蓝斑（LC）神经元的电生理特性与未处理的对照进行了比较。与对照相比，经DSP-4处理的动物的LC神经元的动作电位和Ca2+尖峰（在TTX存在下引发）持续时间显著缩短。这些观察结果表明，用DSP-4进行化学性轴突切断会降低蓝斑神经元中的Ca2+电导。
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