[临床及实验性坏死性肝硬化肝脏的免疫形态学研究]
[Immunomorphological study of the liver in clinical and experimental postnecrotic cirrhosis].
作者信息
Berezhkova R V, Romanov V A
出版信息
Arkh Patol. 1978;40(8):38-42.
Immunomorphological study of the liver was carried out in 5 dead patients with postnecrotic cirrhosis of the liver and in 50 white rats with experimental cirrhosis of the liver for the purpose of detection of fixed immunoglobulins localization. Saturation with gamma-globulins of the vessel walls, forming connective-tissue septae and hepatocytes undergoing degeneration was established in rats. In man, gamma-globulins were found in the connective tissue strands, in vessel walls, and in the cytoplasm of mesenchymal cells and hepatocytes. The analysis of the results suggests different origin and dissimilar importance of gamma-globulins in different structures of the liver.
为检测固定免疫球蛋白的定位，对5例死于肝坏死性肝硬化的患者及50只实验性肝硬化大白鼠的肝脏进行了免疫形态学研究。在大白鼠中发现，形成结缔组织间隔的血管壁及发生变性的肝细胞存在γ球蛋白浸润。在人类，结缔组织束、血管壁以及间充质细胞和肝细胞的细胞质中均发现了γ球蛋白。结果分析表明，γ球蛋白在肝脏不同结构中的来源不同，重要性也不同。
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