Takai T, Li M, Sylvestre D, Clynes R, Ravetch J V
DeWitt Wallace Research Laboratory, Sloan-Kettering Institute, New York, New York 10021.
Cell. 1994 Feb 11;76(3):519-29. doi: 10.1016/0092-8674(94)90115-5.
The gamma subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgG (Fc gamma RIII) and is associated with the high-affinity receptor for IgG (Fc gamma RI) and the T cell receptor-CD3 complex. It is required for both receptor assembly and signal transduction. Targeted disruption of this subunit results in immunocompromised mice. Activated macrophages from gamma chain-deficient mice unexpectedly lack the ability to phagocytose antibody-coated particles, despite normal binding. Defects in NK cell-mediated antibody-dependent cytotoxicity and mast cell-mediated allergic responses are evident in these animals, establishing the indispensable role of FcRs in these responses. However, loss of gamma chain does not appear to perturb T cell development, since both thymic and peripheral T cell populations appear normal. These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses.
免疫球蛋白Fc受体的γ亚基是IgG高亲和力受体（FcγRIII）的重要组成部分，并且与IgG高亲和力受体（FcγRI）和T细胞受体-CD3复合物相关联。它对于受体组装和信号转导都是必需的。该亚基的靶向破坏会导致免疫受损的小鼠。来自γ链缺陷小鼠的活化巨噬细胞出乎意料地缺乏吞噬抗体包被颗粒的能力，尽管结合正常。这些动物中自然杀伤细胞介导的抗体依赖性细胞毒性和肥大细胞介导的过敏反应存在缺陷，这确立了FcRs在这些反应中的不可或缺的作用。然而，γ链的缺失似乎不会干扰T细胞发育，因为胸腺和外周T细胞群体看起来都是正常的。因此，这些小鼠是评估这些受体在体液免疫和细胞免疫反应中作用的重要工具。
