Ratnavel R C, Burrows N P, Pye R J
Department of Dermatology, Addenbrooke's Hosital, Cambridge, UK.
Clin Exp Dermatol. 1994 Jan;19(1):83-5. doi: 10.1111/j.1365-2230.1994.tb01126.x.
The follow up of a case of the carcinoid syndrome complicated by scleroderma is reported, in which progress of the disease may have been halted by treatment with a combination of cyproheptadine, parachlorophenylalanine and prednisolone. Impairment of tryptophan and 5-hydroxytryptamine (serotonin) metabolism appears central to the development of skin fibrosis in the carcinoid syndrome and may be indicative of important mechanisms in the pathogenesis of idiopathic scleroderma.
本文报告了一例类癌综合征合并硬皮病的病例随访情况，该病例中，通过联合使用赛庚啶、对氯苯丙氨酸和泼尼松龙进行治疗，疾病进展可能已得到控制。色氨酸和5-羟色胺（血清素）代谢受损似乎是类癌综合征皮肤纤维化发展的核心，可能提示特发性硬皮病发病机制中的重要机制。
