使用治疗剂量的顺二氨二氯铂（CDDP）治疗卵巢癌患者可消除抑制细胞活性。
Abrogation of suppressor cells activity by cis-diamminedichloroplatinum (CDDP) treatment using therapeutic doses in ovarian cancer patients.
作者信息
Tsuda H, Kitahashi S, Umesaki N, Kanaoka Y, Kawabata M, Ogita S
机构信息
Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan.
出版信息
Gynecol Oncol. 1994 Feb;52(2):218-21. doi: 10.1006/gyno.1994.1034.
We examined the activity of natural killer (NK) cells and suppressor cells and the population of peripheral blood lymphocytes before and after cis-diamminedichloroplatinum (CDDP) treatment using therapeutic doses in 15 ovarian cancer patients. CDDP did not decrease NK cell activity but selectively abrogated suppressor cell activity up to 7 days after treatment (P < 0.05). The CD56+CD16+ cell and CD8+CD11+ T cell populations significantly decreased; however, the CD4+2H4+ T cells, showed a significant increase after treatment (P < 0.05). We conclude that CDDP treatment using therapeutic doses could selectively abrogate suppressor cell activity.
我们使用治疗剂量的顺二氯二氨铂（CDDP）对15例卵巢癌患者进行治疗，检测了治疗前后自然杀伤（NK）细胞和抑制细胞的活性以及外周血淋巴细胞的数量。CDDP并未降低NK细胞活性，但在治疗后长达7天的时间里选择性地消除了抑制细胞活性（P<0.05）。CD56+CD16+细胞和CD8+CD11+T细胞数量显著减少；然而，CD4+2H4+T细胞在治疗后显著增加（P<0.05）。我们得出结论，使用治疗剂量的CDDP治疗可选择性地消除抑制细胞活性。
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