Noris P, Bertolino G, Previtali M, Ferrario M, Balduini C L
Department of Internal Medicine, University of Pavia-IRCCS S. Matteo, Italy.
Haemostasis. 1993 Jul-Aug;23(4):185-91. doi: 10.1159/000216874.
We investigated ex vivo spontaneous platelet aggregation (SPA) in platelet-rich plasma in 37 patients with acute myocardial infarction. It occurred in about 50% of subjects receiving heparin after streptokinase treatment, while it rarely took place in patients who did not receive either streptokinase or heparin and in those treated with streptokinase alone. The study of patients receiving heparin for deep vein thrombosis suggested that SPA may derived from adenosine diphosphate released from platelets during sample handling. We suggest that heparin infusion may facilitate ex vivo platelet activation and that this mechanism is operative in patients with acute myocardial infarction who have undergone thrombolytic therapy.
我们研究了37例急性心肌梗死患者富血小板血浆中的离体自发性血小板聚集（SPA）情况。在链激酶治疗后接受肝素治疗的患者中，约50%出现了这种情况，而在未接受链激酶或肝素治疗的患者以及仅接受链激酶治疗的患者中很少发生。对接受肝素治疗深静脉血栓形成的患者的研究表明，SPA可能源于样本处理过程中血小板释放的二磷酸腺苷。我们认为肝素输注可能促进离体血小板活化，并且这种机制在接受溶栓治疗的急性心肌梗死患者中起作用。
