Paradisi R, Grossi G, Venturoli S, Porcu E, Rocchi G, Pasquali R, Capelli M, Flamigni C
Institute of Reproductive Physiology and Pathology, S. Orsola Hospital, University Alma Mater Studiorum of Bologna, Italy.
Horm Res. 1993;39(5-6):223-8. doi: 10.1159/000182740.
The role of dopaminomimetic drugs on the brain catecholamine metabolism in the neuroendocrine regulation of the polycystic ovary syndrome (PCO) was investigated. We measured, besides peptide hormones and sex steroids, urinary dopamine (DA), norepinephrine, epinephrine, vanillylmandelic acid, homovanillic acid (HVA), 3,4-dihydroxyphenylacetic acid (DOPAC) and total 3-methoxy-4-hydroxyphenylglycol (MHPG) levels by high-performance liquid chromatography with electrochemical detector in 10 women with PCO before and during long-term bromocriptine (BRC) administration. HVA and DOPAC concentrations were significantly lower (p < 0.001) in PCO patients compared with 12 control subjects in the early follicular phase, whereas MHPG concentrations were significantly higher (p < 0.01) in PCO patients. During BRC administration, HVA, DOPAC and MHPG levels increased significantly (p < 0.01 for HVA and DOPAC, and p < 0.05) for MHPG), prolactin levels dropped markedly (p < 0.01), whereas luteinizing hormone levels did not change (p = NS). These data show (1) a reduced DA activity in PCO which may be normalizable under BRC treatment, but also (2) no major effects of DA metabolism on the inappropriate gonadotropin secretion of the syndrome.
研究了多巴胺模拟药物在多囊卵巢综合征（PCO）神经内分泌调节中对脑儿茶酚胺代谢的作用。除肽类激素和性类固醇外，我们还通过高效液相色谱-电化学检测器测量了10例PCO女性在长期服用溴隐亭（BRC）之前和期间尿中多巴胺（DA）、去甲肾上腺素、肾上腺素、香草扁桃酸、高香草酸（HVA）、3,4-二羟基苯乙酸（DOPAC）和总3-甲氧基-4-羟基苯乙二醇（MHPG）的水平。与12名处于卵泡早期的对照受试者相比，PCO患者的HVA和DOPAC浓度显著降低（p < 0.001），而PCO患者的MHPG浓度显著升高（p < 0.01）。在服用BRC期间，HVA、DOPAC和MHPG水平显著升高（HVA和DOPAC为p < 0.01，MHPG为p < 0.05），催乳素水平显著下降（p < 0.01），而促黄体生成素水平未改变（p =无显著性差异）。这些数据表明：（1）PCO中DA活性降低，在BRC治疗下可能恢复正常；（2）DA代谢对该综合征不适当的促性腺激素分泌无主要影响。
