Axelson H, Panda C K, Klein G
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Int J Cancer. 1994 Feb 1;56(3):418-21. doi: 10.1002/ijc.2910560322.
The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.
鲁汶大鼠自发产生的免疫细胞瘤（RIC）存在6号和7号染色体之间持续的染色体易位。这种易位使免疫球蛋白重链和c-myc序列并列。在早期对14个RIC肿瘤的研究中，我们发现10个肿瘤的易位断点位于c-myc上游紧邻的1.5 kb范围内。在此我们描述了3个特殊肿瘤，它们在c-myc 5'端20 kb范围内没有重排。使用脉冲场凝胶电泳我们显示，这些肿瘤中的易位断点位于c-myc 5'端50 - 80 kb处，并且c-myc重排至IgH簇的3'端。
