McCormack D, Jones B, McElwain J, McHale L, McHale A P
Department of Orthopaedics, Meath Hospital, Dublin, Ireland.
Eur J Surg Oncol. 1993 Jun;19(3):232-4.
A potential role of extracorporeal shock wave lithotripsy (E.S.W.L.), in the destruction of tumours has been proposed in recent literature. To examine further this potential, we have studied the effects of E.S.W.L. on the sarcoma-derived osteoblast-like cell line MG-63. An in-situ assay of cell viability was used to establish the cellular response to high energy shock wave therapy. A significant tumoricidal effect was confirmed when the cells were grown and tested in conventional monolayer phase. However cells grown in the three-dimensional matrix of alginate beads were significantly less vulnerable to extracorporeal shock wave therapy as earlier studies have suggested.
近期文献提出了体外冲击波碎石术（E.S.W.L.）在肿瘤破坏中的潜在作用。为了进一步研究这种潜力，我们研究了E.S.W.L.对肉瘤来源的成骨样细胞系MG-63的影响。采用细胞活力原位测定法来确定细胞对高能冲击波治疗的反应。当细胞在传统单层培养阶段生长并进行测试时，证实了显著的杀肿瘤作用。然而，正如早期研究所表明的，在藻酸盐珠三维基质中生长的细胞对体外冲击波治疗的敏感性明显较低。
