Graham M D, Yelland A, Peacock J, Beck N, Ford H, Gazet J C
Surgical Breast Unit, St George's Hospital, Tooting, London.
Eur J Surg Oncol. 1993 Jun;19(3):259-64.
In a retrospective review of 2820 patients with breast carcinoma seen at the Combined Breast Clinic of St George's Hospital over a 23-year period 101 cases were bilateral of which 52 (1.8%) presented synchronously and 49 (1.7%) metachronously. Twenty deaths occurred in the synchronous group after a mean follow-up of 56.2 months and 15 deaths in the metachronous group after a mean follow-up of 48.5 months following diagnosis of the second tumour. If timed from initial presentation patients with metachronous tumours fared better than those with unilateral disease (P < 0.01). There was no significant difference in survival between patients with metachronous (if timed from the second tumour), synchronous or unilateral breast carcinoma.
在对圣乔治医院联合乳腺诊所23年间诊治的2820例乳腺癌患者进行的回顾性研究中，101例为双侧乳腺癌，其中52例（1.8%）为同时性双侧乳腺癌，49例（1.7%）为异时性双侧乳腺癌。同时性双侧乳腺癌组平均随访56.2个月后有20例死亡，异时性双侧乳腺癌组在诊断出第二个肿瘤后平均随访48.5个月有15例死亡。如果从初次就诊开始计算时间，异时性双侧乳腺癌患者的预后优于单侧乳腺癌患者（P<0.01）。异时性双侧乳腺癌患者（如果从第二个肿瘤开始计算时间）、同时性双侧乳腺癌患者或单侧乳腺癌患者之间的生存率无显著差异。
