干扰素治疗慢性活动性乙型肝炎：六个月治疗方案的效果
Interferon treatment of chronic active hepatitis B: effect of a six month treatment regimen.
作者信息
Raptopoulou M, Orphanou H, Vrettou H, Akribiadis E, Chadzikonstantinou L, Goulis G
机构信息
2nd Medical Department, Aristotelian University, Thessaloniki, Greece.
出版信息
Gut. 1993;34(2 Suppl):S102-3. doi: 10.1136/gut.34.2_suppl.s102.
In this study of 17 patients with chronic active hepatitis B, the loss of hepatitis B virus DNA, the return to normal of alanine aminotransferase activities, and histological improvement after six months' treatment with 3 million units three times weekly with interferon alfa-2b, was achieved in 40% of hepatitis B e antigen (HBeAg) positive/anti HBe negative patients, and 41.66% of HBeAg negative/anti HBe positive patients. The reappearance of hepatitis B virus DNA was seen in most patients when treatment was stopped, although a higher percentage of HBeAg positive/anti HBe negative patients (20%) had a sustained loss of hepatitis B virus DNA, return to normal alanine aminotransferase activities, and histological improvement compared with HBeAg negative/anti HBe positive patients (8.3%).
在这项针对17例慢性活动性乙型肝炎患者的研究中，使用干扰素α-2b每周三次、每次300万单位进行为期六个月的治疗后，40%的乙肝e抗原（HBeAg）阳性/抗-HBe阴性患者以及41.66%的HBeAg阴性/抗-HBe阳性患者实现了乙肝病毒DNA消失、丙氨酸转氨酶活性恢复正常以及组织学改善。在大多数患者停药后出现了乙肝病毒DNA再现的情况，不过与HBeAg阴性/抗-HBe阳性患者（8.3%）相比，有更高比例（20%）的HBeAg阳性/抗-HBe阴性患者实现了乙肝病毒DNA持续消失、丙氨酸转氨酶活性恢复正常以及组织学改善。
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