系统性红斑狼疮患者真皮-表皮交界处β1H球蛋白与C3的显示。

Demonstration of beta 1H globulin together with C3 in the dermal-epidermal junction of patients with systemic lupus erythematosus.

作者信息

Carlo J R, Rothfield N F, Ruddy S

出版信息

Arthritis Rheum. 1979 Jan;22(1):13-8. doi: 10.1002/art.1780220103.

DOI:10.1002/art.1780220103

Abstract

Skin lesions and clinically normal skin from 10 patients with systemic lupus erythematosus (SLE) were examined by immunofluorescence for the presence of C3 and its control protein, beta 1H globulin. beta 1Hwas always found in association with deposited C3; in the instance where C3 deposits were not found beta 1H was also not found. Granular deposits of C3 and beta 1H were found in the dermal-epidermal junction (DEJ) in all of the 5 nonlesional skins studied. In the lesional skin, C3 was found in 4 of 5; in 2 of these 4, beta 1H was also found. As previously demonstrated for in vitro systems, beta 1H also binds in vivo to fragments of C3, presumably C3b, generated during activation of the complement system.

摘要

通过免疫荧光法检测了10例系统性红斑狼疮（SLE）患者的皮肤病变部位及临床正常皮肤中C3及其对照蛋白β1H球蛋白的存在情况。总是发现β1H与沉积的C3相关联；在未发现C3沉积的情况下，也未发现β1H。在所研究的全部5例非病变皮肤的真皮 - 表皮交界处（DEJ）发现了C3和β1H的颗粒状沉积。在病变皮肤中，5例中有4例发现了C3；在这4例中的2例中，也发现了β1H。如先前在体外系统中所证明的，β1H在体内也与补体系统激活过程中产生的C3片段（可能是C3b）结合。