Arndt J W, van der Sluys Veer A, Blok D, Griffoen G, Verspaget H W, Lamers C B, Pauwels E K
Department of Diagnostic Radiology and Nuclear Medicine, University Hospital, Leiden, The Netherlands.
J Nucl Med. 1993 Jul;34(7):1052-7.
In a prospective comparative study of 14 patients with inflammatory bowel disease (IBD), the abilities of 99mTc-HMPAO labeled white blood cells (WBCs) and 111In-granulocytes to assess the presence and location of active disease were compared. The two examinations were carried out within 2 wk of each other. Scintigraphically concordant positive or discordant segments were evaluated by radiologic or endoscopic examination performed within 14 days. When bowel segments were compared, concordance was found for 102/111 (91.8%) segments between 99mTc-WBC images obtained at 1 hr after injection and 3-hr 111In-granulocyte images. For five of five 99mTc-WBCs positive/111In-granulocyte negative segments, it could be proven that the 99mTc-WBC result was caused by active disease. For patients, 99mTc-WBC scintigraphy detected four more patients with active disease than 111In-granulocytes (11 and 7 patients, respectively). Technetium-WBCs was superior in the assessment of active disease, especially for small bowel segments. We conclude that early imaging 1 hr after the injection of 99mTc-WBCs can reliably replace 111In-granulocyte scintigraphy in IBD patients because the radiopharmaceutical is available on a daily basis. Thus, there is less radiation burden to the patient and cell separation is simpler and less time-consuming.
在一项针对14例炎症性肠病（IBD）患者的前瞻性对照研究中，比较了99mTc-HMPAO标记的白细胞（WBC）和111In-粒细胞评估活动性疾病的存在及位置的能力。这两项检查在彼此两周内进行。通过在14天内进行的放射学或内镜检查评估闪烁图像上一致的阳性或不一致的节段。当比较肠段时，在注射后1小时获得的99mTc-WBC图像与3小时的111In-粒细胞图像之间，102/111（91.8%）的节段显示一致。对于5个99mTc-WBC阳性/111In-粒细胞阴性节段中的5个，已证实99mTc-WBC结果是由活动性疾病引起的。对于患者，99mTc-WBC闪烁扫描检测出活动性疾病患者比111In-粒细胞多4例（分别为11例和7例）。锝标记的白细胞在评估活动性疾病方面更具优势，尤其是对于小肠节段。我们得出结论，在IBD患者中，注射99mTc-WBC后1小时进行的早期成像可可靠地替代111In-粒细胞闪烁扫描，因为该放射性药物每天都有。因此，患者的辐射负担更小，细胞分离更简单且耗时更少。
