Clerici N, Fernández M, Saiz I, Sainz T, Polanco I
Servicio de Inmunología, Hospital Ramón y Cajal, Madrid, Spain.
J Pediatr Gastroenterol Nutr. 1993 May;16(4):381-6. doi: 10.1097/00005176-199305000-00006.
Class I and II human leukocyte antigens were determined by a standard microlymphocytotoxity test in a group of 45 pediatric patients with selective immunoglobulin A deficiency (IgA-D), 33 of them with frequent respiratory tract infections, allergic diseases, or gastrointestinal disorders (RTIAG), and 12 with celiac disease (CD). The results showed that the DR1 allele, and the A1, B8, Cw7, DR3, DQw2; B35, Cw4, DR1, DQw1; and B14, DR1, DQw1 haplotypes could be involved with IgA-D susceptibility in RTIAG patients. Among the CD-IgA-D group, the B14 allele and A1, B8, Cw7, DR3, DQw2 haplotype were found to confer a high risk of developing IgA-D. A possible protective role may be postulated for DR2 and DR4 in both types of IgA-D patients. The present study confirms some of the previous findings in other white populations and describes new possible alleles and haplotypes that could be implicated with IgA-D susceptibility and resistance.
通过标准微量淋巴细胞毒性试验，对45例选择性免疫球蛋白A缺乏症（IgA-D）的儿科患者进行了I类和II类人类白细胞抗原检测，其中33例患有频繁呼吸道感染、过敏性疾病或胃肠道疾病（RTIAG），12例患有乳糜泻（CD）。结果显示，DR1等位基因以及A1、B8、Cw7、DR3、DQw2；B35、Cw4、DR1、DQw1；和B14、DR1、DQw1单倍型可能与RTIAG患者的IgA-D易感性有关。在CD-IgA-D组中，发现B14等位基因和A1、B8、Cw7、DR3、DQw2单倍型具有发生IgA-D的高风险。对于两种类型的IgA-D患者，DR2和DR4可能具有保护作用。本研究证实了先前在其他白种人群中的一些发现，并描述了可能与IgA-D易感性和抗性有关的新的等位基因和单倍型。
