Robertson W D, Wray D
Department of Oral Medicine & Oral Pathology, University of Edinburgh, Scotland.
J Oral Pathol Med. 1993 Apr;22(4):180-2. doi: 10.1111/j.1600-0714.1993.tb01053.x.
Biopsies of non-ulcerated oral mucosa from 13 patients with oral lichen planus and 12 patients with leukoplakia were immunohistochemically stained using monoclonal antibodies to pan T, pan B, T helper and T suppressor/cytotoxic cells and the stained lymphocytes enumerated using an image analyser. The results show the preponderance of T cells infiltrating both oral lichen planus and leukoplakia. The T helper: T suppressor/cytotoxic cell ratio was the same (1:2) for both oral lichen planus and leukoplakia. A similar proportion of T suppressor/cytotoxic cells was found infiltrating the epithelium. These data indicate that T cell subset analysis is of no value in distinguishing oral lichen planus from other oral keratoses.
对13例口腔扁平苔藓患者和12例白斑患者的非溃疡性口腔黏膜活检标本进行免疫组织化学染色，使用针对全T细胞、全B细胞、辅助性T细胞和抑制性/细胞毒性T细胞的单克隆抗体，并使用图像分析仪对染色的淋巴细胞进行计数。结果显示，浸润口腔扁平苔藓和白斑的T细胞占优势。口腔扁平苔藓和白斑的辅助性T细胞与抑制性/细胞毒性T细胞的比例相同（1:2）。发现浸润上皮的抑制性/细胞毒性T细胞比例相似。这些数据表明，T细胞亚群分析在区分口腔扁平苔藓与其他口腔角化病方面没有价值。
