Tachibana C, Satoh K, Ohe Y, Hashimoto N, Furuya Y
Department of Anesthesiology, Tokyo Women's Medical College Daini Hospital.
Masui. 1993 Apr;42(4):574-8.
The effects of epidural buprenorphine (Bn) under nitrous oxide-oxygen-enflurane (E) anesthesia in elderly patients were examined. The subjects were older than 65 years (n = 82) and scheduled for abdominal surgery. They were divided randomly into two groups according to epidural drugs used. The first group received epidural Bn 0.1-0.2 mg (group B, n = 41). The second group received epidural Bn 0.1-0.2mg + 1% lidocaine (group BL, n = 41). The enflurane concentration was 1.13% in group B, and it was significantly higher than 0.78% of group BL (P < 0.01). There was no intra-group difference in the highest systolic blood pressure during operation. The lowest systolic blood pressure during operation was 92.0 +/- 2.1 mmHg in group BL and it was significantly lower than 100.2 +/- 2.9 mmHg of group B (P < 0.05). The percentage of patients who needed vasoconstrictor drugs was 12% in group B, and it was significantly smaller than 42% of group BL (P < 0.01). On the other hand the percentage of patients who needed vasodilator drugs was 39% in group B, and it was significantly larger than 17% of group BL (P < 0.05). There was no intra-group difference in arousing time from anesthesia. Concerning the postoperative respiratory state, there was no intra-group difference in the respiratory rate, tidal volume and PaO2. But the PaCO2 value was 44.7 +/- 0.8 (mean +/- SE) mmHg in group BL, and it was significantly higher than 40.7 +/- 0.7 mmHg of group B (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
研究了老年患者在氧化亚氮-氧气-安氟醚（E）麻醉下硬膜外注射丁丙诺啡（Bn）的效果。受试者年龄大于65岁（n = 82），计划进行腹部手术。根据使用的硬膜外药物将他们随机分为两组。第一组接受硬膜外注射0.1 - 0.2mg丁丙诺啡（B组，n = 41）。第二组接受硬膜外注射0.1 - 0.2mg丁丙诺啡 + 1%利多卡因（BL组，n = 41）。B组的安氟醚浓度为1.13%，显著高于BL组的0.78%（P < 0.01）。手术期间最高收缩压在组内无差异。手术期间最低收缩压在BL组为92.0±2.1 mmHg，显著低于B组的100.2±2.9 mmHg（P < 0.05）。需要血管收缩药物的患者百分比在B组为12%，显著低于BL组的42%（P < 0.01）。另一方面，需要血管扩张药物的患者百分比在B组为39%，显著高于BL组的17%（P < 0.05）。麻醉苏醒时间在组内无差异。关于术后呼吸状态，呼吸频率、潮气量和动脉血氧分压在组内无差异。但BL组的动脉血二氧化碳分压值为44.7±0.8（均值±标准误）mmHg，显著高于B组的40.7±0.7 mmHg（P < 0.01）。（摘要截断于250字）
