Satoh K, Satoh Y, Imagawa J, Taira N
Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Jpn Heart J. 1993 Mar;34(2):213-9. doi: 10.1536/ihj.34.213.
The cardiotonic effect of pimobendan was studied in 6 dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. Pimobendan in doses of 1-10 mg improved cardiac function in a dose-dependent manner and at 10 mg improved it beyond the control. These doses of pimobendan, however, produced neither a significant increase in heart rate nor arrhythmias. The results indicate that the drug may be of use in the treatment of heart failure.
在6个因戊巴比妥而导致心功能严重受抑制的犬心肺制备标本中研究了匹莫苯丹的强心作用。剂量为1 - 10毫克的匹莫苯丹以剂量依赖的方式改善了心功能，在10毫克时其改善程度超过了对照组。然而，这些剂量的匹莫苯丹既未使心率显著增加，也未引起心律失常。结果表明该药物可能可用于治疗心力衰竭。
