Kato S
Department of Pediatrics, Tokai University School of Medicine.
Rinsho Ketsueki. 1993 May;34(5):545-50.
Bone marrow transplantation (BMT) has been increasingly applied to a variety of potentially fatal diseases in childhood. However, trends of indication of BMT are changing because chemotherapy in leukemia and immunosuppressive therapy with/without colony stimulating factor in aplastic anemia are improving. Several progresses have been noted in matched unrelated BMT and peripheral blood stem cell transplantation as well as in sibling BMT or autologous BMT. Many efforts are being made to decrease rejection rate or leukemia relapse and to improve quality of life by new conditioning regimens. Attempts to induce GVL effects or syngeneic GVHD are currently under progress. The quality of life in long term surviving children are generally good and acceptable, although delay in growth, infertility, cataract and obstructive lung disease are seen in a few patients.
骨髓移植（BMT）已越来越多地应用于治疗儿童各种潜在的致命疾病。然而，由于白血病化疗以及再生障碍性贫血使用或不使用集落刺激因子的免疫抑制治疗正在改善，BMT的适应证趋势正在发生变化。在匹配的无关供者BMT和外周血干细胞移植以及同胞BMT或自体BMT方面也取得了一些进展。人们正在通过新的预处理方案努力降低排斥率或白血病复发率，并改善生活质量。目前正在进行诱导移植物抗白血病（GVL）效应或同基因移植物抗宿主病（GVHD）的尝试。长期存活儿童的生活质量总体良好且可以接受，尽管少数患者出现生长发育迟缓、不育、白内障和阻塞性肺病。
