Otsuka M, Ichiya Y, Kuwabara Y, Sasaki M, Akashi Y, Yoshida T, Fukumura T, Masuda K
Department of Radiology, Faculty of Medicine, Kyushu University.
Kaku Igaku. 1993 Apr;30(4):389-95.
Brain perfusion SPECT studies of 123I-IMP and 99mTc-HMPAO were performed in 10 patients with various brain disorders and the difference in the distribution of 123I-IMP and 99mTc-HMPAO in the cortices and striatum was compared with the cerebral blood flow by 15O-PET method. The ratios of the radioactivity in 14 ROIs of the cortices, striatum and cerebellum to that of the reference region or the right frontal cortex were compared among the 3 studies. The coefficient variance between 123I-IMP and PET was 0.71 and that between 99mTc-HMPAO and PET was 0.74 in the regions excluding the striatum. The striatal activity ratio in 123I-IMP was slightly less than those in 99mTc-HMPAO and PET which were close to each other. The visual activity in the striatum in 123I-IMP was also slightly less than those in 99mTc-HMPAO and PET. All the striatal lesions of decreased perfusion diagnosed by PET were observed in 123I-IMP, however 2 lesions were missed in 99mTc-HMPAO. This seems to be relevant to the difference in the distribution of 123I-IMP and 99mTc-HMPAO.
对10例患有各种脑部疾病的患者进行了123I-IMP和99mTc-HMPAO的脑灌注单光子发射计算机断层扫描（SPECT）研究，并通过15O-正电子发射断层扫描（PET）方法将123I-IMP和99mTc-HMPAO在皮质和纹状体中的分布差异与脑血流量进行了比较。比较了这3项研究中皮质、纹状体和小脑的14个感兴趣区（ROI）与参考区域或右侧额叶皮质放射性的比值。在排除纹状体的区域，123I-IMP与PET之间的变异系数为0.71，99mTc-HMPAO与PET之间的变异系数为0.74。123I-IMP中的纹状体活性比值略低于99mTc-HMPAO和PET中的比值，而99mTc-HMPAO和PET中的比值彼此接近。123I-IMP中纹状体的视觉活性也略低于99mTc-HMPAO和PET中的视觉活性。PET诊断为灌注降低的所有纹状体病变在123I-IMP中均被观察到，但在99mTc-HMPAO中漏诊了2个病变。这似乎与123I-IMP和99mTc-HMPAO的分布差异有关。
